Stem Cell Research Goes Underground: The RETINOBLASTOMA-RELATED Gene in Root Development
نویسندگان
چکیده
Both cellular differentiation and stem cell maintenance must occur at the root apex in order to ensure the continuous growth of plant roots. In this issue of Cell, it is revealed that a canonical retinoblastoma pathway plays a crucial role in regulating the balance between differentiation and renewal of plant root stem cells.
منابع مشابه
The RETINOBLASTOMA-RELATED Gene Regulates Stem Cell Maintenance in Arabidopsis Roots
The maintenance of stem cells in defined locations is crucial for all multicellular organisms. Although intrinsic factors and signals for stem cell fate have been identified in several species, it has remained unclear how these connect to the ability to reenter the cell cycle that is one of the defining properties of stem cells. We show that local reduction of expression of the RETINOBLASTOMA-R...
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Mutations that cause lethality in the gametophyte phase pose a major challenge for studying postfertilization gene function. When both male and female haploid cells require a functional gene copy, null alleles cause developmental arrest before the formation of the zygote, precluding further investigation. The Arabidopsis thaliana Rb homolog RETINOBLASTOMA-RELATED (RBR) has an important function...
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ورودعنوان ژورنال:
- Cell
دوره 123 شماره
صفحات -
تاریخ انتشار 2005